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Humboldt-Universität zu Berlin

DFG Research Training Group "Computational Systems Biology"

Biology has developed into a quantitative, information-driven science. We are seeking doctoral students for the DFG-funded Research Training Group "Computational Systems Biology" (CSB) which focuses on the system-level understanding of biological data using computational methods. CSB is embedded in the thriving Berlin life-science environment and involves high-ranking research institutions such as Humboldt-Universität zu Berlin, Freie Universität Berlin, Charité-Universitätsmedizin Berlin, Max Planck Institute for Molecular Genetics and Max Delbrück Center for Molecular Medicine Berlin-Buch.

We are looking for highly-motivated students with a strong interest in systems biology and mathematical modelling. Successful applicants must hold the equivalent of a master's level degree in life sciences, mathematics, biophysics or computer sciences. The PhD positions are offered for 3 years. The salary is according to the German TV E13 scale (65%).

We offer an excellent training program in computational systems biology, supervision by at least two experienced scientists, and multifarious opportunities for developing local and international collaboration.

For online application see here

Application deadline is now 15 October, 2015!
Email contact: info at berlin-csb.de

UPDATE (Feb. 08, 2016):

Since all other CSB positions are filled now we ask applicants only to apply for a position in the group of

Markus Landthaler

We offer 1 PhD positions for the following possible projects:


Variation and genetic control of posttranscriptional regulation
(Markus Landthaler, Uwe Ohler)


Research Questions
Here, we will use our recently developed protein occupancy on mRNA approach in lymphoblastoid cell lines from diverse individuals genotyped in the 1000 genome project to identify cis-regulatory mRNA regions in the human population that are differentially contacted by RNA-binding proteins. In addition, we will use ribosome profiling (Ingolia, Brar et al. 2013) and mRNA half-life measurements (Gregersen, Schueler et al. 2014) to determine which differentially occupied cis-regulatory mRNA regions (Schueler, Munschauer et al. 2014) are associated with mRNA decay and translation. We will computationally integrate this information with available maps of interaction sites of RBPs with their target transcripts (either predicted or experimentally observed) to infer likely candidates that mediate phenotypic variation.
This study will demonstrate the feasibility of unbiased high-throughput quantification of protein-mRNA interactions for personalized genomes. When integrated with decay and protein synthesis information, our approach adds a new dimension to the characterization of gene expression regulation.


Cellular RNA-RNA interactions and their impact on gene regulation

(Markus Landthaler, Nikolaus Rajewsky)


Research Questions
Our studies will enable the functional analysis of physiological RNA structures and will allow us to study the impact of RNA helicases on remodeling of RNA-RNA interaction during mRNA decay. We note that this project is a follow up based on computational work by a CSB funded PhD student Andrei Filipchyk (Grosswendt, Filipchyk et al. 2014) (co-first authors).

Zuletzt aktualisiert am Freitag, den 02. Oktober 2015 um 10:01 Uhr

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Humboldt-Universität zu Berlin is an equal opportunities employer.

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Humboldt-Universität zu Berlin is an equal opportunities employer.

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CSB seminar break

seminars will start again in October 2018

 

 

 

 

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